Head of UMR Inserm Laboratory “Biology of Cardiovascular Diseases”
Our laboratory investigates the role of major signaling pathways (Wnt, Hedgehog, JAK2) in vascular biology and thrombosis during development and disease. We specialize in vascular exploration using transgenic mouse models and signaling pathways. Over the past decade, my research team has been at the forefront, providing molecular and biochemical evidence for the dynamic role of the Wnt/Frizzled pathway in the vascular, cardiac, and central nervous systems. Currently, our group is examining the role of endothelial dysfunction in heart failure and vascular dementia.
Major Contributions to Physiology, Biology, and Vascular Medicine:
- Development of a Mouse Model of Angiogenesis (Hindlimb Ischemia): Conducted studies on risk factors influencing angiogenesis.
- Innovative Methodology for 3D Visualization of Arterial Microvasculature: Utilized a micro-scanner in experimental models.
- Endothelial Dysfunction and Heart Failure with Preserved Ejection Fraction: Provided new insights into mechanisms and potential therapeutic targets.
- Role of Wnt Non-Canonical Planar Cell Polarity Signaling: Investigated its involvement in vascular morphogenesis, endothelial cell polarity, Blood-Brain Barrier integrity, and cognitive impairment.
- Trim47 Role in Cognitive Impairment: Explored its contribution to cognitive dysfunction.
Thierry played in piano bars before going to boarding school, read Chekhov in the village squares of Aveyron, and also believes that southern cuisine is a metaphor for southern culture.
