{"id":2400,"date":"2024-08-05T12:21:53","date_gmt":"2024-08-05T10:21:53","guid":{"rendered":"https:\/\/vbhi-institute.org\/?p=2400"},"modified":"2024-08-09T12:22:46","modified_gmt":"2024-08-09T10:22:46","slug":"white-matter-hyperintensity-and-dementia","status":"publish","type":"post","link":"https:\/\/vbhi-institute.org\/en\/white-matter-hyperintensity-and-dementia\/","title":{"rendered":"White matter hyperintensity and dementia"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row][vc_column][vc_column_text css=&#8221;&#8221; el_class=&#8221;intro&#8221;]In this study, researchers wanted to investigate the causal association between white matter hyperintensity (WMH) burden, clinical stroke, blood pressure (BP), and dementia risk, while accounting for potential epidemiologic biases.[\/vc_column_text][vc_column_text css=&#8221;&#8221;]\n<h2>Design<\/h2>\n<p>This study first examined the association of genetically determined WMH burden, stroke, and BP levels with Alzheimer disease (AD) in a 2-sample mendelian randomization (2SMR) framework. Second, using population-based studies (1979-2018) with prospective dementia surveillance, the genetic association of WMH, stroke, and BP with incident all-cause dementia was examined. Data analysis was performed from July 26, 2020, through July 24, 2022.<\/p>\n<h2>Measures<\/h2>\n<p>The association of genetic instruments for WMH, stroke, and BP with dementia was studied using GWASs of AD (defined clinically and additionally meta-analyzed including both clinically diagnosed AD and AD defined based on parental history [AD-meta]) for 2SMR and incident all-cause dementia for longitudinal analyses.<\/p>\n<h2>Results<\/h2>\n<p>These findings suggest that WMH is a primary vascular factor associated with dementia risk, emphasizing its significance in preventive strategies for dementia. Future studies are warranted to examine whether this finding can be generalized to non-European populations.<\/p>\n<h2>Scientific publication<\/h2>\n<p>Sargurupremraj M, Soumar\u00e9 A, Bis JC, et al. <em>Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia.<\/em> JAMA Netw Open. 2024;7(5):e2412824. <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2818880\" target=\"_blank\" rel=\"noopener\">doi:10.1001\/jamanetworkopen.2024.12824<\/a>[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Vascular disease is a treatable contributor to dementia risk, but the role of specific markers remains unclear, making prevention strategies uncertain.<\/p>\n","protected":false},"author":1024,"featured_media":2402,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[71],"tags":[],"class_list":["post-2400","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication-scientifique","entry","has-media"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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